Sameer KHAN
Department of Biology and Institute of Biochemistry, Carleton University, Ottawa ON – Canada

Tim XING
Department of Biology and Institute of Biochemistry, Carleton University, Ottawa ON – Canada

https://doi.org/10.47743/jpd.2025.32.1.974

Keywords: gene co-expression, genetic interaction, multi-omics, protein-protein interaction, signaling network.

Abstract: Arabidopsis thaliana mitogen-activated protein kinase (MPK) signaling network plays a role in various cellular processes. This study integrated protein-protein interaction, genetic interaction, and co-expression data from the STRING, BioGRID, and ATTED-II databases to provide a comprehensive dataset of interactions within the network. The key MPK network components from this set were identified and subjected to functional enrichment analysis, which revealed their involvement in diverse biological processes and pathways. This integrative approach, combining multiple sources of evidence, provides a comprehensive approach for understanding Arabidopsis thaliana MPK signaling network. The findings demonstrate the complex regulatory mechanisms that play a role in plant stress responses and development.

How to cite this article:
KHAN S. & XING T. 2025. Investigating the interactome of Arabidopsis thaliana mitogen-activated protein kinases: an integrative approach using multiple sources of evidence. J. Plant Develop. 32: 143-156.
https://doi.org/10.47743/jpd.2025.32.1.974

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